COVID Survivor

Know a patient who is a COVID survivor. He was in the ICU for a month, requiring mechanical ventilation for almost four weeks. That’s much longer than a typical patient with bacterial pneumonia. This patient required a lengthy infusion of the neuromuscular blockade which, along with shock, contributed to the profound weakness. This complication is also called critical illness polyneuropathy. *What can we do during these 4 weeks when the patient is paralyzed to minimize the myopathy and neuropathy that may develop? *Are there treatments or therapies? *Are you familiar with the concept of Disease tolerance and Adaptogens? I’d love to hear others’ reflections on this and if you have any tips for preparation


Thanks @DrSushil Mehra for initiating the discussion on critical illness polyneuropathy and myopathy in patients on prolonged mechanical ventilation.. We can take certain measures to reduce the incidence during ICU care a d after discharge from hospital. But in Indian set up difficult to execute because of mind set .But doctors on curofy can resolve to put it into practice. 1.Early mobilization and early weaning off ventilator should be encouraged. 2.Use of specialized beds which continuously turn patients along the longitudinal axis up to 60 degree on each side with pre- set degree and speed of rotation. Prestigious institutes can use such beds in ICU- as these are already in use in Wuhan and other countries. 3.Prone position during mechanical ventilation should be used particularly in respiratory conditions like ARDS , viral pneumonia which not only improves PaO2 / FiO2 , but also reduces myopathy. 4.Passive limb exercises and passive pneumatic compressions in such patients on ventilatory support will reduce myopathy and polyneuropathy . 5.Neuromuscular electrical stimulation in ICU in lower limb muscles have some benefits. 6 Once patient is discharged as in your patients case- medications which I have found useful in clinical practice for myopathy are tab Go - Cram or Cramnil containing magnesium bisglycinate 360 mg B.D - as magnesium deficiency is seen in such patients. Addition of L - carnitine 500 mg B.D and CO- Q- 10 B.D gives dramatic results besides O.R.S . Disease tolerance concept should not be confused with resistance or immune tolerance. Disease tolerance protects by promoting host health while having positive effect on pathogen illness .Innate immunity or herd immunity does increase disease tolerance. Environmental factors play most important role - particularly increased gut microbiotica ( Use of pre- probiotics) have now been considered for increasing host tolerance. T- cell exhaustion as in this case do help in host tolerance. Adaptogens - may increase resistance to physical and mental stress to chronic illness .Most popular adaptogen being used is Ginseng and other herbal products. These are used in Russia , Korea and china .Ot late in india Patanjali products like Giloy Ghanvati , Aloe vera juice , amla juice are increasingly used as adaptogens .But adaptogens have not been approved in pharmacology and clinical practice settings and further studies are needed to get official approval
Jyotishmati (malkangani) is very much effective in Neuropathy. But it's very difficult to swallow as taste is very odd. If it's made available in the form of capsule then it's easy to ingest ( I mean swallow).

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Premature discussion ,we are not guided be guildlines issued by various authorities from time to time. We may discuss about various aspect of sing ,symptoms and treatment part of COVID 19 but few of our colleagues are in vary tight spot who make experiment under current situation on human life .so it good for discussion ,pl don't make management chart or experiment on precious human life.follow line of management as directed by Govt / WHO or any other competent authority issued or briefed everyday .
Thanks Dr Parveen Yograj

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It’s still an infant,we don’t know how it’s behaving & we depending upon each institution inputs. All management r dictated by Govt./ AIIMS/WHO Guidelines. In my opinion we can use the drugs,whatever available to us in trial basis or empirical therapy, unless strict guidelines comes to the force.( my personal view)
Usual period recommended for ventilatory support is 2 weeks. Critical illness neuropathy and Myopathy is not documented on COVOD 19. GBS is already documented after the recovery of COVID 19. NeedsNCV to exclude GBS ,if not done better to do. For critical illness neuropathy & myopathy as you know preventive and supportive care only reported.
As inputs came related to IL6 As this looks to immunity suppressant Interlukins may be choice
Thanx dr Bichitrananda Mishra

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Good Nutritious diet Pregabalin+ Methylcobalamin Immunosante
Agreed with Dr.Madhukar D
Critical illnes neuropathy or myopathy had poor out come and one of the cause of prolong ventilator support and delayed weaning off from ventilation...there is no proper treatment of both only strictly rbs control is required And should be rouled out other causes of neuropathy and myopathy with ncv and emg
Was that supported by ncv,emg ,in addition what were the antibiotics given to him & was there any bacterial supper added infection ,did the pt have pseudo cholinesterase deficiency , after all these considerations , one can think of critical illnesses neuropathy
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