Cause of multiple ivf failure ( 3 Times ) karyotype both partners normal .

Abnormal uterine anatomy, non- receptive endometrium and medical condition of mother can adversely affect the cross- talk between the embryo and the endometrium that is crucial for successful implantation Following three consecutive IVF failures, patient should undergo hysteroscopy to assess the uterine cavity. 3D ultrasound as well as HSG may be used. Once an abnormality associated with implantation failure is recognized, treatment options should be considered to be considered include uterine septectomy, removal of intra uterine adhesions, endometrial polypectomy or myomectomy and excision of hydrosalpinx. Also undergo blood test for hemophilia and connective tissue diseases
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Other causes to be ruled out Medical problems or local problems
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