Stem cells and cancer cells

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Hayflick Limit is a concept that helps to explain the mechanisms behind cellular aging. The concept states that a normal human cell can only replicate and divide forty to sixty times before it cannot divide anymore, and will break down by programmed cell death or apoptosis.
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Hayflick limit or Hayflick phenomenon is the number of times a normal human cell population will divide before cell division stops. The concept of Hayflick limit was given by American anatomist Leonard Hayflick in 1961 . In Hayflick limit cells lose their capacity to divide over time unless they become cancerous. Hayflick limit defines the number of possible cell division and depends on the length of chromosomal telomeres , which decreases in standard cells with every cell division.
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The phenomenon is characterized by the limited number of times a normal cell population would divide mitotically until it stops dividing and become senescence .This phenomenon is postulated to occur as a result of telomere shortening triggering DNA damage response.

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