a 2months baby , look his/her eyes , the sign is by birth ...

Good evening Curofians. Spotter : Eye A. What is your diagnosis? B. Describe your findings. C. What is your next step? D. Differential diagnosis. Thank you. (Courtesy : Internet)

Pt. Syria soni , aged 3 years , Female child , suffering from low vision BE . clinical observation shows Congenital Leucoria with searching rotatory nystagmus . There is H/O premature delivery of 7 months duration . Mother was suffering from fever during pregnancy period also. child's V/A Perception of light BE . Pls suggest diagnosis and further management also .

1.5yr male arrived in OPD with Opacity of b/l pupils since 5 months ,, no other complaint What is spot diagnosis??? Kindly add your expert opinion

Leukocoria (also leukokoria or white pupillary reflex) is an abnormal white reflection from the retina of the eye. . . Leukocoria resembles eyeshine, but leukocoria can occur in humans and other animals that lack eyeshine because their retina lacks a tapetum lucidum. . Leukocoria is a medical sign for a number of conditions, including Coats disease, congenital cataract, corneal scarring, melanoma of the ciliary body, Norrie disease, ocular toxocariasis, persistence of the tunica vasculosa lentis (PFV/PHPV), retinoblastoma, and retrolental fibroplasia. . Because of the potentially life-threatening nature of retinoblastoma, a cancer, that condition is usually considered in the evaluation of leukocoria. In some rare cases (1%) the leukocoria is caused by Coats' disease (leaking retinal vessels).