Is Plasma Therapy The Way Forward of Covid 19?

A 49-year-old patient was admitted to Max Super Speciality Hospital, Saket on the 4th of April exhibiting moderate symptoms of COVID-19. By the 8th of April, he was in respiratory failure and required ventilator support. The hospital was following procedures laid down by the Ministry of Health and Family Welfare; he was being treated for symptoms and was on the hydroxychloroquine and azithromycin combination as well. Still, he wasn’t getting better. This is when the family stepped in and requested the hospital to try convalescent plasma therapy on compassionate grounds since it is still an experimental technique in the context of COVID-19. They managed to find a donor, and on the 14th of April, the transfusion took place. Max Hospital doctor who oversaw blood plasma treatment in COVID-19 patient in Delhi explains how the therapy works Representational image. Image by Ahmad Ardity from Pixabay. Both of the patient's parents had also contracted the novel coronavirus. While, unfortunately, his father passed earlier this month, his mother has recovered. MyUpchar spoke with Dr Sandeep Budhiraja, Group Medical Director, Max Healthcare and Senior Director, Institute of Internal Medicine, who oversaw the blood plasma treatment, to find out more about the procedure. The promise and limits of plasma therapy “Plasma therapy can be attempted in cases that are moderate to severe. The patient, in this case, was experiencing respiratory distress, had developed acute pneumonia, and was not responding to other medication. It is not a therapy that will work if the patient is on the brink, though,” Dr Budhiraja explained. When asked if plasma therapy can be used preventively or prophylactically, the doctor said that this was not the purpose of its application. “Plasma therapy can be thought of as an added support to the body when it is overpowered by an acute infection. Antibodies from an external source may strengthen the body’s attack on the pathogen and help the patient overcome a difficult situation”, he said. Who can donate blood plasma? Convalescent plasma therapy, or passive antibody therapy, involves taking the blood plasma of a recovered patient and transferring it to an infected person. The antibodies produced by the survivor persist in the body for a period of time (depending on the infection) and provide varying degrees of immunity by mounting a swift attack should the body encounter the pathogen again. “In this case, the donor had previously been infected with COVID-19 and subsequently tested negative twice. A healthy and suitable donor is one with no underlying conditions and who has been declared negative for at least two weeks. We also checked for Hepatitis B, C and HIV, all of which were clear,” he said. He added that serological (or antibody) tests could not be performed, but it was reasonable to assume that the donor had sufficient antibodies since they had cleared the disease. The recovery The patient seemed to respond well to the treatment and was gradually weaned off the ventilator on the 18th of April. As of Sunday, April 19, he was able to eat and has since tested negative. “However, it is important that we also understand that plasma therapy is no magic bullet. During the patient’s treatment, other standard treatment protocols were followed. Plasma therapy could have worked as a catalyst in speeding up his recovery. We cannot attribute the recovery to plasma therapy completely, as there are multiple factors which carved that path,” the doctor added. Trials are ongoing in India and abroad. Plasma therapy could be promising until a vaccine is produced. Cases such as these may spur scalability initiatives; blood banks could identify and take plasma from COVID-19 survivors to provide for compassionate cases and clinical trials. Source: firstpost

14 Likes

LikeAnswersShare
Yes sir plasma therapy is not a first step nor it is dependable it is advised for critically ill with covid19 with comorbidies At early stages to use plasma therapy neither advisable nor recovery can be assumed . It is in trials.
Thanx dr Vipin Bihari Jain
0

View 2 other replies

Informative post
Verymuch useful information given.thankyou Doctor
0
This is one good example of plasmat therapy and plasma taken form one who has been cured from Covid19. Yesterday in news paper (. Telegraph) where Dr Sara Gilbert of Oxford University claims that she is almost in the verge of come out with vaccine and is in trial on animals and going to start on human and she is using the antibody form plasma form patient who has recovered for Cobid 19 . I can give the details if somebody is interested.
Thank you doctor
0

View 3 other replies

Though there aren't much supporting documentation on this modality of treatment but still it is showing dramatically improving in patients' condition. If we wait for the approval of this, which takes a long time basing on different studies, we might loose many patients. So my opinion is that ICMR should take necessary steps for it's approval (be it on a temporary basis) for the betterment of Mankind, especially in India.
Thanks Dr @Santu Das , Dr @Ram Gupta , Dr @Vipin Bihari Jain
1

View 3 other replies

Yes , plasma of a fully cured COVID 19 patient is not a therapy it is a catalyst in speeding up recovery . Treatment protocols must be followed strictly actually we are at junction where we ready to adopt because we are loosing battle as in case of HQC in America now the new is mortality is high. Vaccination can solve our problem if is not a case of biological weapon or mutation.
Thanks Dr Vipin Bihari Jain
0

View 2 other replies

Plasma therapy is promising in treatment of COVID19, since there are no effective prevention and treatment so far . With the patient on ventilator, and gradually multi organ failure setting in , we do not have any more options . Such cases it is worthwhile trying this . With more experience and studies , this can be standardised and evaluated .
Appreciate your efforts Enlightening to know it... but all this can be overcome by a gift of God...ginger...a small piece of ginger to chew raw and every twenty minutes... inhale steam and gargles of rock salt and turmeric powder... every half hour...all goes away on its own
Plasma beneficial fair trial in serious pt covid pt negative four weeks with good covid antibodies donation of one pt is good for 4 pt 200 ml is dose
Plasma therapy is a good catalyst in recovery as other standard treatment protocols were followed. Nice attempt
THESE ARE MY COMMENTS REGARDING THE TREATMENT AND PROPHYLAXIS OF COVID 19 SO FAR THEIR IS NO DEFINITE TREATMENT OF THIS DISORDER TILL EE GET THE VACCINE WHEN THE VACCINE WILL COME WE DONT KNOW CHLOROQUINE IS THOUGHT TO BE A PROPHYLACTIC TOOL FOR PATIENT'S OF COVID 19 BECAUSE OF ITS IMMUNOTHERAPEUTIC AND ANTIVIRAL ACTION HOWEVER STILL THIS IS NOT THE DEFINITE TREATMENT THIS DRUG MAY REDUCE THE SEVERITY OF DESEASE THEN WE CANT GIVE THIS DRUG BLINDLY BECAUSE OF ITS OCCULAR SIDE EFFECTS ALSO GIVING PLASMA THERAPY TO EVERY PATIENT OF COVID 19 MAY NOT BE PRACTICAL
Load more answers

Cases that would interest you