DD generalised OEDEMA since 6 months?investigations? rx

Baby brought by the parents with the distended abdomen. Whats diagnosis according to you.

15 yr male pt suffering from swelling over face n leg...n pitting type of edema present plz Tel me diagnosis n treatment

5yr old, came with Abd distension and occasional constipation... Spot the dx...

5yr old pt, 15.8kg, 87cm came frfollow up. visited previously in september with c/o constipation. noticed coarse facies, anemia, abd distension, umblical hernia, short stature, delayed bone age. usg revealed minimal pericardial effusion. thyroid profile with TSH 750 attached pt was put on Rx, continued frm local practitioners and since then returned now. current thyroid profile with TSH 100 also attached. pt is taking 50mcg levothyroxin so far... discuss any further investigation & rx...