60 yr old man c/o darkening of skin at groin and axilla. O/E:warty, velvety brown skin Biopsy : hyperplastic epidermis with peaks and valleys. What could be the etiological factor.?Which malignancy is commonly associated with this condition? 1--Diabetes 2--Immunosupression 3--Infectiin 4--Skin Malignancy

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NORMALLY. .... IN. DIABETES. AND. OBESITY...... ...THE. INCREASED..... TRASFORMING. GROWTH. FACTOR...( T G F )..... Is. the. mechanism. for.... SKIN. MALIGNANCY. RELATED ACANTHOSIS. NIGRICANS. ..

Diabetes &.. Paraneoplastic phenomenon, most frequently in association with adenocarcinoma of gastrointestinal origin

Diiabetes

Tnx sir
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As per biopsy it is 4 skin malignancy But also seen as manifestations in diabetes

Thanx dr Pushkar Bhomia
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Commonly in Diabetes mellitus as acanthosis nigricans

1- DIABETES

Thanks Dr Dinesh Gupta
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Diabetes

1 - Diabetes

Manifestation of diabetes

1 diabetes

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