What CNS physiological changes occur during a seizure?

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Conclusion: During a seizure,blood flow and glucose utilization in the brain are increased.Accompanying the neuronal activity may be an increase in lactate,decrease in pH,alteration in the concentration of neuro transmitters,an increase in extracellular potassium,decrease in extracellular calcium. Generalized tonic clonic seizures and most complex partial seizures activate the hypothalamus and increase serum prolactin,a finding that may help to differentiate epileptic from non- epileptic seizures .Prolactin also may be elevated after syncope and hence cannot differentiate seizures from syncope.
DURING A SEIZURE, LARGE GROUPS OF NEURONS ARE ACTIVATED REPETITIVELY AND HYPERSYNCHRONOUSLY........ THERE IS FAILURE OF INHIBITORY SYNAPTIC CONTACT BETWEEN NEURONES.... AND THIS CAUSES EEG High-tech VOLTAGE SPIKE--AND--WAVE ACTIVITY, WHICH IS THE ELECTROPHYSIOLOGICAL HALLMARK OF EPILEPSY...... THANKS MAM... IF I WENT IN NERVE ACTION POTENTIAL THEN I HAVE TO OPEN MY BOOK OF GALLEN'S PHYSIOLOGY.
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