CRYPTOCOCCUS NEOFORMANS MENINGITIS IN AIDS

CRYPTOCOCCUS NEOFORMANS The leading cause of menigitis in AIDS patients occurs when CD4+ T cell count < 100 cells / μL Most patients present with SUBACUTE MENINGOENCEPHALITIS CSF Protein - ↑ CSF WBC count - ↑ CSF pressure - ↑ CSF Glucose -↓ Diagnosis: - CSF microscopy- INDIA INK STAIN- Cryptococcus neoformans yeast cells Cryptococcal Antigen(CrAg) detection through Latex Agglutination Test (LAT). TREATMENT: Induction : IV / Liposomal Amphotericin B + Flucytosine × 2 weeks......followed by Amphotericin alone until CSF culture turns negative. Maintenance: Oral FLUCONAZOLE until CD4+ T-cell count > 200 cells /μL× 6 months in response to cART. PROPHYLAXIS: oral FLUCONAZOLE whenc CD4+ T-cell count < 100 cells /μL

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Cryptococcus neoformans is ab encapsulated yeast (fungus)

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