Is treatment for PAH for whole life or we can tapper the dose of bosentan etc.

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Bosentan is an oral medication classified as an endothelin receptor antagonist (ERA) which is approved for the treatment of pulmonary arterial hypertension (PAH) in World Health Organization (WHO) Group 1 patients. The goal of this therapy is to improve exercise ability and slow progression of the disease. Tapering doses after complete recovery.. But on maintenece dose one has to thru out life except hepetotoxicity.
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It is almost for life time Yes after loading doses of 62.5 mg od and pts recovered to be maintained on half the dose
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