A case of β-thalassemia

Chief Complaint A 54 y/o male, carrier of the β-thalassemia trait presented with anemia. Vitals BP:125/80 mmhg, Resp rate: 17 bpm, Pulse: 73 bpm, Temp: 98.6 degree F Investigations CBC shows pancytopenia, WBC: 3.4 × 103/μl, HB: 5.9 g/dl, MCV: 63.7 fl, platelets: 47 × 103/μl, neutrophils: 1.2 × 103 /μl and lymphocyte count 2.4 × 103/μl. Peripheral smear shows microcytic hypochromic anemia & neutropenia. Bone marrow aspiration & biopsy shows hypercellular marrow with 95% of nucleated cells being blasts of lymphoid features. Immunophenotyping diagnosed B-cell common acute lymphoblastic leukemia. Karyotype was normal. Treatment How should we proceed further?

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Absolutely pt is in acute lymphoid leukaemia Yes bone marrow radiotherapy(targeted) BONE MARROW TRANSPLANT difficult to get for thalasemia

Thanx dr Kute Ankush
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Acute lymphoblastic leukemia Need chemotherapy Adv Refer to oncologist

NEED'S.. HEMATO ONCOLOGISTS OPINION FOR FURTHER MANAGEMENT..

Tnx Dr Dinesh Gupta
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MOSTLY RADIATION THERAPY. BETTER TO TAKE HEMATO ONCOLOGIST OPINION.

Whole blood transfusions first then specefic anabolic steroids

Is beta thal trait confirmed by hplc?

Refer to Oncologist for further management

Refer the patient to medical Oncologist for chemotherapy

Oncologist/haematologist opinion to be taken

TREATMENT BY RADIATION

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