A young male with Cholangitis

Friends, I am presenting a very important case scenario for discussion. Let's go step by step: 35 years old lady, no comorbidities, good performance status, presented with obstructive jaundice for 1 month. Apart from icterus rest of the examination was normal. At presentation, s. Bill 10, ALP 300. MRCP and CECT films are presented. How to proceed further? If want further relevant investigation I'll provide.

A 45 yr old lady, presented with history of pain abdomen for 4 weeks and jaundice for 5 days. USG revealed gallstones and a dilated CBD. Bilirubin was 5mg%, and SGOT/SGPT 102/88. Alkaline phosphatase was 481. The patient underwent MRCP, which also revealed dilated CBD till lower end, however, no CBD stone could be seen. What could be the diagnosis? How to proceed with the case?

28yr/M, k/c/o Cholelethiasis, presented with Pain Abdomen, Pain Chest, SOB. He is non DM, non Hypertensive, Serum Amylase, Lipase within Normal limits. He is having 'Jaundice'.

52/female brought to casualty in drowsy state with c/o progressively increasing jaundice since 2 months for which they were taking some ayurvedic medicines from a quack.  pt is non alcoholic, no h/o blood transfusion, fever, no h/o significant weight loss.  o/e- drowsy, pulse- 110/min, BP- 90/60. spo2 98% on air. icterus, pallor and pedal edema present.  P/A- liver palpable 4 cms and free fluid present.  within 1 hour of admission she started with profuse malena and hematemesis.  Ix showed Hb (6.8), TLC (10,300), Plt (4.17L), Total Bil (18), direct (10) indirect (8), OT/PT (265/121), Albumin (3.5),Globulin (3.1), serum ammonia 250, HBSAg, HCV negative, INR (1.8), Urea (46), creat (1.9), Na (145), K (2.9).  Diagnostic Ascitic tap was done and report attached (ADA and cytology awaited). USG and CT abdomen attached.  could it be malignancy?  can obstructive jaundice present directly at this terminal stage? patient had no h/o abdominal pains before and had no h/o gall stones.  Budd Chiari? 

Plain X-ray Abdomen taken before scheduling for Lap cholecystectomy. What is clinical scenario