Gliclazide or Glimipiride Which type of diabetic patient to prescribe it?

(Edited)

1 Like

LikeAnswersShare
Both Gliclazide and Glimipiride are antidiabetic drugs comes under sulfonylurea group to treat Type 2 DM.Gliclazide is second generation of sulfonylureas where as Glimipiride is third generation of sulfonylureas. Gliclazide is short acting where as Glimipiride is long acting drug. Gliclazide has additional Cardiovascular benefits as it has anticoagulant effect. So that in diabetic patients with cardiovascular disease has addon benefit with use of Gliclazide. Glimipiride facilitates cardioprotective effect elicited by ischemic preconditioning in the Diabetic heart. Gliclazide can be indicated in Type 2 DM DKD Metformin intolerance Underweight Type 2 DM Special occasions like Ramzan fasting to prevent hypoglycemia.
Whenever you want to add sulfonilureas These both molecules are vary good potent molecules to lower the blood sugar and to lower hba1c either as single or in combination of other molecules like metformin and pioglitazone as per need These are long acting molecule with lesser incidences of hypoglycemia Only problem of beta cell apoptosis
Thank you doctor
0

View 2 other replies

Both are sulfonylureas with good control of Hba1c. Risk.of hypoglycemia is always there so keep this in ur mind before prescribing to elderly .. In some studies glimipiride is CVS safe ..but overall they both are CV neutral.
IN CASE OF.. DM-II .. WITH HIGH BSL.. CAN BE GIVEN IN KIDNEY DISEASE.. CAN BE GIVEN WITH METFORMIN..
Thank you doctor
0

View 2 other replies