Why Breast Ca more common in nulliparous??

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1.Due to lowering endogenous estrogen levels in nulliparous women than in multiparous women 2.There is,shortening of duration of estrogen exposure in nulliparous women 3.Due to shortening of estrogen exposure in nulliparous women angiogenesis which is under influence of estrogen exposure and Vascular endothelial growth factor A ( VEGFA) is inhibited .As there are decreased levels of VEGFA in nulliparous women due to less estrogen exposure- angiogenesis which is stimulator of malignancy in breast is inhibited
Nulliparous is associated with increased risk of certain reproductive malignancy It may be due to increased number of ovulatary cycle can be prevented by use of oral contraceptives
hormones causing carcinoma abundantly present in nilliparous female eg estrogen
@due to estrogen..
A recent commentary in The Lancet summarized the available evidence based on data in nulliparous women and concluded that the risk of nulliparity was related to the increased number of ovulatory cycles, and so might be preventable by utilization of oral contraceptives. That communication described significant differences in age-dependent cancer mortality in nulliparous nuns, as well as in parous controls, between breast, ovarian and uterine cancers. Moreover, the steep inclines in cancer mortality in nuns are only observed decades after the menopause
In conclusion, it is suggested by Reproductive enfocronologist that nulliparity and parity differently modulate ovarian VEGFA/VEGFR2 system and that more favorable conditions to potentially altered ovarian angiogenesis more likely occur in nulliparous than in parous females.
Pregnancy reduce breast cancer risk through induction of persistent changes of the mammary gland that make the breast less susceptible to carcinogenic factors.
Hormone dependency leads that
Hormonal depended

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