Blood Count May Offer Clues to Treatment of COVID-19

The severity of COVID-19 illness may be influenced by what researchers call "cytokine storms." In a new study, investigators assessed 522 COVID-19 patients, aged 5 days to 97 years, who were admitted to two hospitals in Wuhan, China, in December and January. The study also included a "control group" of 40 healthy people. Compared to the control group, 76% of COVID-19 patients had significantly lower levels of T cells -- a type of white blood cell that plays a crucial role in immune response against viral infections. Patients admitted to the intensive care unit had much lower T cell counts than those who didn't require ICU care. Patients over age 60 had the lowest T cell counts, the findings showed. And the T cells that did survive in COVID-19 patients were exhausted and unable to function at full capacity, the study authors said. COVID-19 patients also had high levels of cytokines -- a protein that normally helps fight off infection. Too many cytokines can prompt an excessive inflammatory response called a "cytokine storm," which causes the proteins to attack healthy cells. That suggests the new coronavirus does not attack T cells directly. Instead, it triggers the cytokine release, which results in the loss and exhaustion of T cells, according to the authors of the study published May 1 in the journal Frontiers in Immunology. The study results provide new clues on how to treat COVID-19, the researchers said. "We should pay more attention to T cell counts and their function, rather than respiratory function of patients," study author Dr. Yongwen Chen of Third Military Medical University in Chongqing, China, said in a journal news release. Chen added that "more urgent, early intervention may be required in patients with low T lymphocyte counts." In addition, he noted, future research should focus on pinpointing subgroups of T cells that may be most important in COVID-19, along with identifying drugs that boost T cell counts and functioning. Source-https://www.drugs.com/news/blood-count-may-offer-clues-covid-19-study-89971.html

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VERY USEFUL INFORMATION REGARDING COVID 19 INFECTION 1. LYMHOCYTOPENIA... 2. CYTOKINE STORM.... IT FORMS THE BASIS OF NEW MODEL OF TREATMENT OF CORONA OR COVID 19 INFECTION...... ITS A POSITIVE DEVELOPMENT IN MANAGEMENT OF COVID 19 ....
Very important point for information
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Useful updates
Thanx dr Dinesh Gupta
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Intresting t cell studies
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Informative update
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