Best time of day to give Febuxostat/Allopurinol?How to decide/titrate dose?Based on Uric acid level?
Usually suggested to give in morning af5er breakfast Since fabuoxate is once daily hence morning time is good so as to not only decrease the levels but not to allow increase as after food intake Alluprinol is used twice or thr8ce bcz of half life but yes single dose of 300mg is also available which can be given after breakfast. Since this has G I adverse effects to be understood.
Febuxostat is best taken in the morning. You can take febuxostat with or without food. Keep taking febuxostat every day, to prevent gout attacks. At levels above 8 mg % Febuxostat 80 mg should be started with and if Allopurinol is to be used dose is 300 mg O.D. Once S Uric acid level falls below - Febuxostat dose should be 40 mg as maintenance dose and Allopurinol 100 mg B.D as maintenance dose Febuxostat is superior to Allopurinol in lowering the s.uric levels . But Febuxostat should not be used in CVS disease or renal disease or hepatic disease. Although in renal and hepatic disease even Allopurinol is not safe . But cardiac arrhythmias, stroke is one of the conditions where Allopurinol should be preferred
Morning time for Febuxostat. Dise ..If Hyperuricemia level is 8 + start Febuxostat 80 mg OD, x for 1 week, followed by 40 mg OD once for 3 months.
Febuxostat is stated at 40 mg daily and then stepped up to 80 mg daily Allopurinol started as 100 mg daily and then stepped up to 300 mg daily Escalation of dose of depending on serum uric acid level It is better to wait for 2 - 3 month for uric acid to come down, then step up the dose Febuxostat is preferred because of better safety profile Febuxostat and allopurinol both are preferably taken in morning
Take febuxostat at the same time each day. It is best taken in the morning. You can take febuxostat with or without food. Keep taking febuxostat every day, to prevent gout attacks
In the morning
NICELY DISCUSSED.. BY. THE RESPECTED. DRs.. THANKS. DR
I am agree with@Dr. Shivraj Agarwal Sir.
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