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How can be ESR reduced in Atharalgia cases?

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ESR is only a test to diagnose certain diseases. Raised ESR ,by itself ,is not a disease. ESR is rate of sedimentation of rbcs by rouleux formation . Increased fibrinogen or other para proteins will make sedimentation faster . The negative charge of RBC s will resist it. It is increased in all inflammatory conditions like RA, RF, IBD, Auto immune disorders , because of increase in fibrinogen and other inflammation mediators. Infection, like TB raise ESR in the same way. In hypercoagulable states like polycythemia and CCF , ESR is reduced. Pregnancy is a physiological state where ESR is increased . So, if the disorder causing raise in ESR is treated with specific drugs, the abnormal hematological status due to the disease regress ,and ESR comes to normal. DMARD are to be given in RA ,and the ESR also comes down , with clinical improvement.
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ESR is only a test to diagnose certain diseases. Raised ESR ,by itself ,is not a disease. ESR is rate of sedimentation of rbcs by rouleux formation . Increased fibrinogen or other para proteins will make sedimentation faster . The negative charge of RBC s will resist it. It is increased in all inflammatory conditions like RA, RF, IBD, Auto immune disorders , because of increase in fibrinogen and other inflammation mediators. Infection, like TB raise ESR in the same way. In hypercoagulable states like polycythemia and CCF , ESR is reduced. Pregnancy is a physiological state where ESR is increased . So, if the disorder causing raise in ESR is treated with specific drugs, the abnormal hematological status due to the disease regress ,and ESR comes to normal. DMARD are to be given in RA ,and the ESR also comes down , with clinical improvement.
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