COMBINATION OF SOFOSBUVIR + DACLATASVIR IN SEVERE HOSPITALISED COVID19

Dear my friends and fellow Colleagues, Here is an update on the Combination Therapy of SOFOSBUVIR PLUS DACLATASVIR in severe Hospitalised COVID-19 patients. An inexpensive two drug regimen of Sofosbuvir plus Daclatasvir given for 14 days is effective in reducing the recovery time & improving the survival in patients hospitalised with severe COVID-19. This treatment combo has well established safety profile in treatment of Hepatitis C. A small study from Iran at Virtual COVID conference, July, 2020. Regards and thanks, Dr Sepuri Krishna Mohan

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As usual a wonderful update Dr Mohan. The two well established drugs which were used in the treatment of Hepatitis C now became the promising drugs in the treatment of severe hospitalised Covid 19 Patients. These drugs can interfere with RdRp enzyme of novel corona virus which helps it multiply. The Daclatasvir is more effective of the two as it penetrates in to lungs where Covid 19 infection is often concentrated. Significantly faster rate of clinical recovery amd discharge were seen in people with Covid 19 who are on this two drug combination. Faster rates of survival is seen with these drugs. The death rate is 5% with these drugs compared to the20% for people on standard care. According to the scientists , 94% of hospitalised Covid 19 Patients who were given the combination of Sofosbuvir and Daclatasvir had reduced fevers and improve breathing as opposed to 70% of those who did not get this combination. Thanks for sharing the update.

Thanks Dr Devi for your wonderful explanation on my update.
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The fact that there are too many drugs ""effective " against COVID infection , is itself an indicator that none of these drugs is completley effective . We have had this scenario in the past and present, --- malignancies, Collagen vascular disorders, MS, dengue, SARS , H1NI ..... But none of these diseases were killers like COVID. It is discouraging that even after 7 months, we are not able to identify a vaccine or curative agent. But this is WORLD WAR 3, and battle is going to be long and hard and as Dr Ashok Leel pointed out , a lot of precious lives are going to be lost. But we can not afford to lose heart and every new effort has to be lauded but critically scrutinised. We may yet have a Fleming or Banting - Best , come out with a solution. Thank you for bringing light in these dark times ,Dr Krishna Mohan, with your updates.

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Sir , you are working hard to bring updates and regularly doing your duties without failure. Thanks for sharing. But I still strongly believe that we have lost the battle but running pilot to post to find solution . One day they say recovery period is less but has not inform us in which age group and in which sex ,under which condition.next they published like HCQ that in USA drug is useless. Like baba ji why we are running after every thing ,The war is on ultimately we will win after sacrificing lots of precious life. Pl guild us we need it. Regards

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Seems like a small lamp in the middle of the darkness, but still with hope that it will help & lessen the loss of precious lives. Thanks Sir for keeping us updated in the crucial time. Hope you are well and in good health. Regards

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Thank you sir for sharing the useful and informative update as usual.

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Nice information you are working hard, we wishes for best future

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Encouraging post sir plz give us doses of both molecules

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Who was knowing that yet still new drugs r coming as a Sargent to kill COVID viruses. As u have sir,given us a ray of hope that still drugs r there. If u haven't highlightens us we would not have known about these drugs. As ma'm said, old drugs used for hepatitis c is now used for COVID viruses.

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Thanks for sharing sir Very informative discussion

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Nice update Sir regards

Thank you doctor
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