Dear Friends, Fever of unknown origin is a very important clinical condition in our day to day practice.. I thought to have an UPDATE on this The subject needs longer discussions.. So will be presented in two parts Let's have the initial one… Fever of unknown origin (FUO) in adults is defined as a (1)Temperature higher than 38.3 C (100.9 F) (2)Lasts for more than three weeks (3)With no obvious source despite appropriate investigations. COMMON ETIOLOGIES OF FEVER OF UNKNOWN ORIGIN.. INFECTIONS Tuberculosis (especially extrapulmonary) Abdominal abscesses Pelvic abscesses Dental abscesses Endocarditis Osteomyelitis Sinusitis Cytomegalovirus Epstein-Barr virus Human immunodeficiency virus Lyme disease Prostatitis Sinusitis MALIGNANCIES Chronic leukemia Lymphoma Metastatic cancers Renal cell carcinoma Colon carcinoma Hepatoma Myelodysplastic syndromes Pancreatic carcinoma Sarcomas AUTOIMMUNE CONDITIONS Adult Still's disease Polymyalgia rheumatica Temporal arteritis Rheumatoid arthritis Rheumatoid fever Inflammatory bowel disease Reiter's syndrome Systemic lupus erythematosus Vasculitides MISCELLANEOUS Complications from cirrhosis Factitious fever Hepatitis (alcoholic, granulomatous, or lupoid) Deep venous thrombosis Sarcoidosis Drug-induced fever DRUGS COMMONLY ASSOCIATED WITH DRUG -INDUCED FEVER.. Allopurinol Captopril Cimetidine Clofibrate Erythromycin Heparin Hydralazine Hydrochlorothiazide Isoniazid Meperidine Methyldopa Nifedipine Nitrofurantoin Penicillin Phenytoin Procainamide Quinidine The approach to diagnose the patient and investigations needed ...will be covered in the second and concluding part if HELPFUL to you Thanks Dr K N Poddar

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although it is very difficult to cover all test for PUO but a thoughtful line of investigation always gives u diagnosis, and which is also low on pt pocket informative post Dr Poddar

Thanks Dr Sharma for your valuable comments
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A very useful list indeed. Thank you sir. Sad part is quite often some physicians don't think about any d/d for PUO beyond tuberculosis and start empiric ATT without thorough evaluation which proves detrimental for the patient.

Thanks Dr Behera
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An Encyclopedia about PUO.Thanks Dr Poddar

Thanks Dr yograj
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Thanks for sharing.

Thanks Dr Giridhar
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Informative post Dr. Poddar

Thanks Dr jain
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Thank you sir.

Thanks Dr Aswin
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Thanks for sharing this Informative post

Thanks Dr Hemant
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Gud post

nice one sir,,it's weight in golds

Thanks sir

Thanks Dr Pidaparthy
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