Concluded Case

Chronic Myeloid leukemia- Treatment options in Lockdown

A 52 years old male , diagnosed as CML in May 2020 .Patient is now on tab Hydroxyurea 500 mg B.D, Tab Thalidomide 50 mg O.D , Wysolone 30 mg O.D and supportive treatment. Since there is Lockdown- patient is unable to get further oncologic consultation from P.G.I Chandigarh- from where treatment protocol is being followed. Investigations done yesterday showed a massive splenomegaly 22. 2 cms and moderate hepatomegaly.on USG . TLC was 28000 - significantly raised Platelet count- 652 - significantly raised LDH - more than 1200 - significantly raised Any further suggestions regarding management of this case

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Concluded answer
Patient is being planned for further Radiotherapy- a case of CML
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Massive splenomegaly after imatinib..pt may be land up in cml-accelarated phase or call-blast phase Pls ask for peripheral blood examination , BCR-ABL Molecular analysis ..
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Plz do BCR-ABL PHILADELPHIA TRANSLOCATION CHROMOSOME STUDY AND MONITOR CBC EVERY 1 MONTH AND TREATMENT IS CML FOR TAB- IMATINIB 400 MG ( THIS IS CALLED TARGETED THERAPY)
Valuable opinion
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Patient is being planned for further Radiotherapy- a case of CML
BCR - ABL is negative
Must be atypical CML
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