Good evening Curofians. Spotter : Eye A. What is your diagnosis? B. Describe your findings. C. What is your next step? D. Differential diagnosis. Thank you. (Courtesy : Internet)

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retinoblastoma yellowish white pupillary reflex in left eye fundoscopy, b scan, other eye examination congenital cataract ...endohthalmitis....rd ...phpv

Revered Dr. Chandrika Br madam, thank you for your participation. Suggestive key for this case is posted by me, below.
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Retinoblastoma leucocoria CTA scani orbit, screen for other eye, enucleation, radiotherapy, congenital cataract, toxacara canis, PHPV

Revered Dr.Nayeemuddin Mohammed thank you for your participation. Kindly go through the key posted by me.
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A. Leukocoria or Amaurotic cats eye reflex B. The pupil on the left eye of the child shows a characteristic yellowish white reflex when compared to the right pupil which appears jet black. C. D/D... 1. Retinoblastoma 2. Congenital cataract 3. Coats disease or retinal telangiectasia 4. Retrolental fibroplasia 5. Persistent hyperplastic primary vitreous 6. Toxocara endopthalmitis D. The next step in the diagnosis is FUNDOSCOPY. Regards...

i think all D/D have been put toghter. next would be EUA under GA for complete eye assessment followed bya radiological investigation probably CT SCAN
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OSTEOGENESIS IMPERFECTA (brittle bone disease) with ?retinoblastoma

Revered Dr. Zuber Ahmed Khan sir thank you for your participation. Suggestive key for this case is posted by me, below.
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Retinoblastoma is the most common intraocular tumor of childhood. About 75% of the sporadic tumors are caused by somatic mutations and are not transmissible. Sporadic tumors caused by somatic mutations are always unilateral. Unfortunately, unilateral involvement does not exclude heritable disease: about 10% to 15% of infants with unilateral sporadic tumors have heritable germinal mutations. about 90% of patients present with leukocoria, an abnormal, typically white pupillary reflex. Leukocoria is the classic clinical manifestation of retinoblastoma. In the older literature, this finding was fancifully likened to the illuminated tapetal light reflex of the cat (amauroticl cat's - eye reflex). The white pupillary reflex is caused by tumor in the vitreous cavity

Revered Dr. Mohammed Parvez sir thank you for your participation. Suggestive key for this case is posted by me, below.
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retinoblastoma

Revered Dr. Syed Sufiyan sir thank you for your participation. Suggestive key for this case is posted by me, below.
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blue sclera osteogenesis imperfecta and fundus evaluation will tell rest

Revered Dr. Rakesh sharma sir thank you for your participation. Suggestive key for this case is posted by me, below.
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commonly seen in retiniblastoma

Revered Dr. Rajiv K Khandelwal sir thank you for your participation. Suggestive key for this case is posted by me, below.
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leucocoria,

Revered Dr. Reyaz Malla sir, thank you for your participation. Suggestive key for this case is posted by me, below.
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Retinoblastoma showing leucocoria

Revered Dr. Jain madam, thank you for your participation. Suggestive key for this case is posted by me, below.
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