Good morning dear friends and colleagues, Here is an update on Bronze diabetes, otherwise known as Type3 diabetes. With regards, Dr Sepuri Tirumala Devi



Thankyou very much Dr. Tirumala Devi mam for this excellent post. Just to add : Diagnosis :- Hemochromatosis can be diagnosed with a transferrin saturation or serum ferritin blood test, or if needed a DNA blood test to check for the presence of a faulty HFE gene. A liver biopsy may be carried out to assess whether liver damage has occurred. If a close family members diagnosed with hemochromatosis, other family members should be be tested for it. Treatment :- Hemochromatosis is usually treated with regular phlebotomy, a procedure which involves removing iron-rich blood from the body. An alternative treatment is chelation therapy which involves taking a medication called Deferasirox. Treatment for hemochromatosis is off-label as it is has not been clinically trialled for hemochromatosis, but it may be prescribed if you have a condition, such as anaemia or heart disease, which could prevent you having phlebotomy.

Thanks for valuable inputs Dr Puranjoy Saha

Thank you so much for ur wonderful post regarding Bronze diabetes madam. .. is there is any difference in treatment madam?

Thanks Madam Devi for wonderful post

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please elaborate totally mam so that we can learn and more about it

Bronz diabetes is seen in hereditary hemochromatosis. Called so cause of bronz coloured skin and DM. There are 4 types depending on gene involved. Most common is HFE gene on chromosome 6. Hemochromatosis presents in adult age with features of cardiac involvement, pancreatic insufficiency and liver disease. Females are less affected as loss of blood during menstruation is protective. Other features of hemochromatosis include joint involvement - characteristically 1st and 2nd MCP joint, infertility and darkening of skin - due to hemosiderin and melanin. Screening is done with iron studies. Transferrin saturation > 45% is used as cutoff for further testing. Which include evaluation for CLD, DCMP and genetic testing for HFE gene. Treatment is quite simple - periodic phlebotomy to keep ferritin < 100 and transferrin saturation < 50. Other oral iron chelators can be used.

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Good morning mam ! Very nice illustrations of rare congenital disease , Hemachromatosis also known as bronze diabetes due to tanning of skin with diabetes mellitus. Thanks a lot.

Welcome Dr Rabindra kumar

Good morning Tirumala Mam Very informative post. I have not seen even a single case of haemacromatosis in my long practice of fifty years. Either such cases are rare or may be we miss them because we are not aware.

Thanks Dr Jaiparkash

Very nice & useful.

Thanks, sir

very nice info dr devi.

Thanks Dr Viral

Thanks Dr for sharing this valuable informative post

very nice information and post by Dr Devi, Dr satyajit, Dr Sasha

Thanks Dr Kamal

Very nice Dr Devi madam

Thanks, sir
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