In management of sever PPHN case of new born (MAS), on HFV with iNO since 3-4 days. Will Prosta


In Severe PPHN in a new born due to MAS - if neonate is on HFV with iNO - PROSTACYCLIN ( PGI2 ) is a vasodilator through both IV and inhaled route .by activation of adenylase cyclase and inactivated cAMP in pulmonary arterial smooth muscle . Inhalation route is preferred as it is safe . It may act synergistic with iNO causing effective pulmonary vasodilation and also prevent rebound hypertension seen while weaning off iNO ECMO is the last resort