Is it rationale to prescribe ppi with itopride for dyspepsia ? Or itopride alone is enough?

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Itopride is typically taken three times a day...Where as PPI is restricted to twice a day. For dyspepsia Itopride alone is sufficient.. I don't prefer combination of H2Blocker and PPI coz H2 blockers have been showed to carry a lower risk for gastrointestinal infection compared to PPIs. However, when both PPIs and H2 blockers are used together, the further reduction of gastric acid may allow for bacteria to multiply in the digestive system and the risk of infection may be increased.....!!!! More over it is not well noticed that PPI in ling term CAUSE S.MAGNESIUM DEFFICIENCY which is important for production and biosynthesis of 2000+ engymes and hormones ( Refer standard journal of Gastroenterology). Yes, in case to treat GERD combinations of PPI + Domperedone is recommended. Use either of one...Both are good drugs with different pharmacology kinetics.

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I prefer combination of proton pump inhibitor with Itopride This is because both disorders usually occur together Acid peptic disease and decreased motility of stomach - both occur simultaneously in most occasions, therefore it's prudent to give combination when required However, there are rare occasions when only Itopride would be required and no proton pump inhibitor of required such as atrophic gastritis with decreased motility of stomach when only Itopride would be enough

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If dyspepsia is due to GERD due to lax LES , this combination is appropriate. PPI reduces gastric acid. Itopride increases the LES muscle tone and tightens the lax LES.,preventing regurgitation . It also increase gastric motility, there by reducing gastric content.

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Dyspepsia can be in various forms. In functional dyspepsia, if you are suspecting postprandial distress syndrome, then Itopride alone is enough but if it is epigastric pain syndrome, then PPI alone can be given and if mixed symptoms then can be combined.

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Itopride is a colon specific prokinetic and is generally indicated when dyspepsia is associated with constipation. If there is associated APD also then Itopride can be combined with a PPI

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Itopride is a colon spe

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