Is there any role of mannitol in HIE ??

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In Hypoxic Ischemic Encephalopathy , Mannitol reduces cerebral oedema which can cause hypoxic-ischemic brain damage. Not only did mannitol decrease the extent of swelling in the cerebral hemisphere undergoing tissue injury, but the drug also decreased the water content of the non- ischemic, contralateral hemisphere to a similar extent. Despite the reduction in cerebral edema, mannitol therapy was not associated with any ame- lioration in either the distribution or other way.

Role of manitol is to reduce cerebral oedema I agree with dr pharmacokinetics explained by dr Dineshchandra Sharma

I agree with Dr Dinesh Chandra Sharma

Mannitol alleviate cerbral oedema

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