Concluded Case

LSM, METFORMIN IN DPP,DPPOS IS ASSOCIATED WITH LOWER INCIDENCE OF T2DM

Dear my friends and fellow Colleagues, Here is an update on the relationship between LSM Plus Metformin and decreased incidence of T2DM in adults. Adults at high risk for T2DM who had received Lifestyle intervention or Metformin in 3 year DPP (Diabetes Prevention Programme) study & then continued to participate in DPPOS (DPP Outcome Study) were less likely to develop DM compared to placebo group. Participants who did not develop DM also had significantly lower risk of 1) CVD, 2) CKD & 3) Eye disease. 22 years follow up data from DPP. ADA Virual Scientific Sessions, June, 2020 Regards and thanks, Dr Sepuri Krishna Mohan.

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Concluded answer

As per the latest recommendations, Metformin along with life style modifications must be indicated in pre-diabetes because cardiovascular events are equal either in pre-diabetes or in Type 2 DM. So keeping that in view and the usage of Metformin in pre-diabetes along with LSM will prevent the progression of Type 2 DM from pre-diabetes, and this combination will reduce the CV events. It has been shown in all the DPP s Metformin plus LS M is superior to remaining DPP s done with Acarbose Rosiglitazone. Wonderful update Dr Mohan as usual.

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As per the latest recommendations, Metformin along with life style modifications must be indicated in pre-diabetes because cardiovascular events are equal either in pre-diabetes or in Type 2 DM. So keeping that in view and the usage of Metformin in pre-diabetes along with LSM will prevent the progression of Type 2 DM from pre-diabetes, and this combination will reduce the CV events. It has been shown in all the DPP s Metformin plus LS M is superior to remaining DPP s done with Acarbose Rosiglitazone. Wonderful update Dr Mohan as usual.

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