Newborn with isolated odema of feet n hands. Diagnosis ??

A little boy 4 years of age having over weight 26 kg. How to control his obesity and weight ? pls suggest ur valuable opinion

patient reported for bad breathe...age 12yrs...what could b the diagnosis for physical retardation....any syndrome associated?? wht would be the treatment plan...is it turners syndrome??? expertise to answer

Spotter. Diagnosis and DDs ? Investigations warranted and expected abnormality ? Treatment option available??

18 yrs female c/o female pain in abdomen both illiac fossa since 2 yrs absence of menstrual period parent worried about girl USG AND MRI AS FOLLOW WHAT IS D&T/T

ETIOLOGY OF AMENORRHOEA HYPOTHALAMUS || PITUITARY || ENDOCRINE || OVARIAN || OUTFLOW TRACT AXIS HYPOTHALAMUS: Hypothalamic - hypogonadism ×Weight related amenorrhoea (Anorexia nervosa) PITUITARY Pituitary adenoma. Sheehans syndrome ENDOCRINE Hypothyroidism OVARIAN Gonadal dysgenesis/Turner's syndrome. Gonadal failure. PCOS. OUTFLOW TRACT AXIS Congenital absence of uterus and vagina. Vaginal atresia. Imperforate hymen. Any case requires history,examination and investigations for assessment. CLINICAL ASSESSMENT/HISTORY Ask about 1.Regarding menarche and menstrual history. 2.Previous pregnancies-severe PPH (SHEEHAN'S SYNDROME) 3.Weight change-weight loss (ANOREXIA NERVOSA) 4.Hot flushes,decreased libido (PREMATURE OVARIAN FAILURE) 5.Any intake of medications. 6.Contraception. 7.Associated symptoms Cushings disease Hypothyroidism. 8.Previous gynecological history. 9.Chronic illness. CLINICAL ASSESSMENT/EXAMINATION Check for 1.Body mass index-weight loss (ANOREXIA NERVOSA) 2.BLOOD PRESSURE ELEVATED (CUSHINGS,PCOS) 3.Androgen excess Hirsutism-PCOS Virilization-TUMOUR. 4.Secondary sexual characters. 5.Features of Turners syndrome Webbed neck. Short stature. Increased carrying angle at the elbow Sexual infantilism. Widely spaced nipples. 6.Breast examination-galactorrhoea. 7.Any abdominal masses or pelvic masses. 8.Inspection of genitilia Imperforate hymen. Cervical stenosis. 9.Vaginal examination Blind vagina Vaginal atresia. Absent uterus. INVESTIGATIONS OF PRIMARY AMENORRHEA 1.Blood tests. 2.Ultrasound. 3.CT scan of pituitary. 4.Karyotyping. 5.Laparoscopy. SITE OF DISORDER/DIAGNOSIS/TEST Hypothalamus-Hypothalamic-hypogonadism FSH,LH,ESTRADIOL-LOW Pituitary-pituitary adenoma PROLACTIN-HIGH,S.FSH,LH,E2-LOW Ovary-Gonadal dysgenesis-turner syndrome S.FSH,LH-HIGH ESTRADIOL-LOW KARYOTYPING-45XO Mullerian tract Absent uterus-testicular feminization PROGESTERONE CHALLENGE TEST-NEGATIV KARYOTYPING-46XY. Absent uterus-Mullerian agenesis Normal hormonal profile Karyotyping46XY MRI Genital tract-Imperforate hymen S.FSH,LH,E2-NORMAL PCT-NEGATIVE EXAMINATION-IMPERFORATE HYMEN