P A R K I N S O N S D I S E A S E Parkinson’s Disease is a progressive neurological disorder that is caused by a degeneration of cells in the part of the brain that produces the neurotransmitter dopamine (chemical messenger). It is characterised by loss of motor control such as slowness of movement, rigidity, tremor and balance problems as well as non-movement type symptoms including constipation, low mood, fatigue, sleep and memory problems. .Conventional treatment can involve medication which is primarily aimed at increasing dopamine activity. As dopamine is made in the body from amino acids which are the building blocks of protein, diet can play a key part in ensuring that the right nutrients are available to support the body’s ability to produce dopamine. Optimising nutritional status and addressing co-morbidities such as constipation, depression, fatigue, and insomnia is also an area that can benefit through diet. Key dietary factors include reducing toxic load, reducing homocysteine with folic acid, vitamins B12 and B6, zinc and tri-methyl-glycine (TMG) and increasing Omega 3 fats, Vitamin D and Magnesium. DIET AND NUTRITION...KEY FACTORS Optimise your diet, reduce your toxic load While the cause of Parkinson’s is not known, environmental toxins such as pesticides and herbicides are implicated. Researchers have found levels of these chemicals to be higher in the brains of Parkinson’s sufferers and incidence of Parkinson’s is higher in areas with greater use of these chemicals. It makes sense to avoid any environmental toxins that you can. Also, consider your intake of dietary toxins such as alcohol and caffeine – avoiding or reducing these may reduce the load on your body’s detoxification pathways. Homocysteine Homocysteine is an amino acid which is toxic if elevated, and some studies have found that it is elevated in people with Parkinson’s. At this stage it isn’t known whether higher levels of homocysteine contribute to the development of Parkinson’s or whether the Parkinson’s (or Parkinson’s medications) contributes to higher levels of homocysteine, or both. Either way, reducing homocysteine to a healthy level is a good idea. The nutrients needed to reduce homocysteine include folic acid, vitamins B12 and B6, zinc and tri-methyl-glycine (TMG). Some of these nutrients are co-factors for dopamine production too. Increase your omega-3 fats The omega-3’s are anti-inflammatory which may be beneficial as neuro-inflammation is a feature of Parkinson’s. Mood problems are also a common feature and there has been a lot of research into the mood-boosting properties of the omega-3 essential fats. A small placebo-controlled pilot trial reported significantly greater improvement of depression in Parkinson’s patients treated with omega-3 fatty-acid supplementation versus placebo. The richest dietary source is from fish such as salmon, mackerel, herring, sardines, trout, pilchards and anchovies. Vitamin D Vitamin D is a hot topic for research since it was discovered that we have receptors for this vitamin in the brain, and that it enhances brain-derived neurotrophic factor (BDNF – think of this as akin to a growth hormone for neurons), and is anti-inflammatory. This nutrient is mainly provided by the action of sunlight on the skin. Up your magnesium Magnesium is a mineral that acts as a natural relaxant. Some indications of deficiency are: muscle tremors or spasm, muscle weakness, insomnia or nervousness, high blood pressure, irregular heartbeat, constipation, hyperactivity, depression. Magnesium’s role in supporting good sleep may also be quite important here, since many people with Parkinson’s experience poor sleep patterns.

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Good info sir. Some pep comments which will enhance the clarity... 1) The tremor of PD is ' rest tremer' as against ' intention tremor of cerebellar disease. Both r involuntary. Classically the pt is said to carry even a old newspaper in hands(action of some sort!) to hide his rest tremor The regidity is extra pyramidal ( cogwheel or lead pipe type) as against UMN lesions where the regity is called ' claspknife'. The gait is called ' shuffling gait'- it is more of run than walk. The stooping posture on walking is likened to ' as if trying to catch up with cetre of gravity '. The slowness of movements is called ' piverty of movements ' Link with metformin is not yet clear.

Thank you for sharing information Sir. Very helpful. Alongwith Diet, and medication beginning Physiotherapy early on helps to manage the condition better. The physiotherapy is targetted to getting better movement and also getting more socially out of the patient by having group therapy, excursions, etc with the patient since mood tends to be low in patients with Parkinson's... There is Parkinson's Disease Society that is an NGO and it's best to recommend patients to join it.. they have group sessions , interactive sessions with other patients with Parkinson's and their families and this provides great moral support to the patient and caregiver. Consider holistic approach. Thank you

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Very nice presentation about Parkinson.Thnx for sharing sir

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