Parents with a history of consanguineous marriage, twin babies

Anesthesia

Parents with a history of consanguineous marriage, twin babies presented with the complaints of non healing ulcer and I personally noticed short and stout upper limb fingers. My thought goes for collagen disorders.Suggestions, diagnosis and further management please.

1 of 5

https://media.curofy.com/23730.1361b23c8949c9c3a71e513a2e55c341.jpg

10 Likes

LikeAnswersShare

22 Answers10 Likes

Dr. Amol Mohite

Pediatrics

Acrodermatitis enteropathica is a rare inherited form of zinc deficiency, characterized by periorificial and acral dermatitis, alopecia, and diarrhea. Patients have a history of refractory diarrhea, failure to thrive, irritability, dermatitis, and alopecia that gradually appeared shortly after weaning from breast milk. Occasionally, patients have a history of siblings or other family members with similar symptoms in infancy.Physical signs and symptoms are as follows: General: Infants are typically irritable and often inconsolable, and they show a slowing or cessation of growth and development skin dry reythematous scaly,patches and plaques are present and may evolve into crusted, vesiculobullous, erosive, psoriasiform, and pustular lesions. Lesions are predominantly distributed in a periorificial and acral pattern and may .become secondarily infected withStaphylococcus aureusorCandida albicans. Mucosa: Findings include angular cheilitis, glossitis, conjunctivitis, blepharitis, punctate keratopathy, and photophobia. Nails: Paronychia and nail dystrophy are typical. Hair: Patients have loss of scalp hair, eyebrows, and eyelashes.