Quick Recall
Which of the following are contraindicated in patients on sulfonamides?
- A. Parenteral anticoagulants
- B. Oral anticoagulant
- C. Albumin
- D. All of the above
- E. None of the above
SUGGESTIVE. OF .. . .C .. ALBUMIN.. THE. EVIDENCE. IN. VARIOUS. RESEARCH. HAS. PRESENTED. THAT... ..FRACTIONS. .OF. SULFONAMIDES..... ..WHICH. ARE.. ...ALBUMIN. BOUND....... .... ..LACK. IN. ANTIBACTERIAL. ACTION.... SO.... ALBUMIN. SHOULD. BE. AVOIDED. .WITH. SULFONAMIDES. .. MOREOVER.. SULFONAMIDES. CAN. DISPLACE.. ..ANTICOAGULANTS... FROM. PROTEIN BINDING. SITES.....RESULTING. ....IN. TOXIC. EFFECTS. OF. ANTICOAGULANTS....SO.. ..DOSE. ADJUSTMENT. OF. ANTICOAGULANTS. WITH. SULFONAMIDES. ..NEEDED...
The correct answer is, "B. Oral Anticoagulants are contraindicated in patients on sulfonamides"
Sulphonamides are not frequently used to avoid side effects.
A
SULFONAMIDE -ACETYLATION METABOLIC REACTION REACTION SO ENZYME INDUCER ALSO INCREASE METABOLISM OF ANTICOAGULANT ALBUMIN IS EASILY REPLACEABLE FROM PBP BY SULFONAMIDE EX. NEONATAL JAUNDICE
B.oral anticoagulant
C Albumin b/c Albumin decreased effect of sufonamide in bacterocidal process
Oral anti
Yes
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