Quick Recall

Patient N comes to the ER with severe hypoglycemia. She is a type 2 diabetic and is on a regular prescription of anti-diabetics including glimepiride. Which of the following interaction with glimepiride could be the cause of her severe hypoglycemia ?

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SUGGESTIVE. OF ...*C*... MICONAZOLE.. WITH. CONCOMITANT. USE.... ......AZOLE. ANTIFUNGALS... ..INHIBIT. THE. ABSORPTION. OF. GLIMEPIRIDE....SO... SERUM. CONCENTRATION. OF GLIMEPIRIDE. INCREASES. ..AND. RESULTS. IN. SEVERE. HYPOGLYCEMIA..

The correct answer is, "Miconazole"

Oral miconazole & oral aminovulenic acid can cause hypoglycemia use of glimepride

Miconazole can increase glimepiride blood levels causing hypoglycemia.

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