## QUICK REVISION: MEN SYNDROME: PHYSIOLOGY/PATHOLOGY/ENDOCRINOLOGY ## MEN 1 Syndrome - Also called Werner Syndrome - Mutation of MENIN gene - Manifestations include: a. Pituitary adenomas b. Parathyroid adenomas c. Endocrine Pancreatic tumors ___________________________ MEN 2 Syndrome - Mutation of RET proto oncogene - It is of 3 types:- a. MEN 2A: Also known as Sipple Syndrome. Manifests as Parathyroid tumors, Pheochromocytoma and Medullary thyroid carcinoma b. MEN 2B: Also known as MEN 3 sometimes. Manifests as Pheochromocytoma, medullary thyroid carcinoma, maranoid features and mucosal paraganglionomas. c. FAMILIAL MEDULLARY THYROID CARCINOMA

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Thankj Dr Megha sharing this case To add a little information MEN - Multiple Endocrine Neoplasia Type 1 can be remembered by the 3 Ps ie Pituitary Tumors ( Prolactinomas); Pancreatic Endocrine Tumors and Primary Parathyroidism ( most common manifestation) Also Duodenal gastrinomas are also frequently seen ; others include carcinoid tumors , thyroid and adrenocortical adenomas MEN 1 syndrome is caused by germline mutation of MEN 1 Tumor suppressor gene which encodes menin MEN 2 A Sipple Syndrome caused by germline gain of function mutation in RET proto oncogene ; MEN 2 A is commonly employed for genetic screening because medullary carcinoma is a life threatening disease which can be prevented by early thyroidectomy

Thank you Sir for the elaborate information
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Thanks for sharing

Glad you liked it ma'am
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Thanks for your helpful post. ..

Thank you for the appreciation sir
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Thanks for sharing!!

Nice post Dr megha

Nice.

Thank you sir
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Nice presentation

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