## QUICK REVISION: MEN SYNDROME: PHYSIOLOGY/PATHOLOGY/ENDOCRINOLOGY ## MEN 1 Syndrome - Also called Werner Syndrome - Mutation of MENIN gene - Manifestations include: a. Pituitary adenomas b. Parathyroid adenomas c. Endocrine Pancreatic tumors ___________________________ MEN 2 Syndrome - Mutation of RET proto oncogene - It is of 3 types:- a. MEN 2A: Also known as Sipple Syndrome. Manifests as Parathyroid tumors, Pheochromocytoma and Medullary thyroid carcinoma b. MEN 2B: Also known as MEN 3 sometimes. Manifests as Pheochromocytoma, medullary thyroid carcinoma, maranoid features and mucosal paraganglionomas. c. FAMILIAL MEDULLARY THYROID CARCINOMA



Thankj Dr Megha sharing this case To add a little information MEN - Multiple Endocrine Neoplasia Type 1 can be remembered by the 3 Ps ie Pituitary Tumors ( Prolactinomas); Pancreatic Endocrine Tumors and Primary Parathyroidism ( most common manifestation) Also Duodenal gastrinomas are also frequently seen ; others include carcinoid tumors , thyroid and adrenocortical adenomas MEN 1 syndrome is caused by germline mutation of MEN 1 Tumor suppressor gene which encodes menin MEN 2 A Sipple Syndrome caused by germline gain of function mutation in RET proto oncogene ; MEN 2 A is commonly employed for genetic screening because medullary carcinoma is a life threatening disease which can be prevented by early thyroidectomy

Thank you Sir for the elaborate information

Thanks for sharing

Glad you liked it ma'am

Thanks for your helpful post. ..

Thank you for the appreciation sir

Thanks for sharing!!

Nice post Dr megha


Thank you sir

Nice presentation

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