ROLE OF Intravenous Immunoglobulin (IVIG) in COVID 19 Patients?

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.Intravenous immuno-globulin ( IVIG ) have a definite role in COVID-19 patients . Although the mechanisms are not yet precisely understood, reduction in the inflammatory mediators following IVIG therapy suggests that IVIG might target cytokine storm in severe and critically ill COVID‐19 patients by complement scavenging, inhibition of innate immune cells and effector T‐cell activation. Although current batches of IVIG could neutralise seasonal coronavirus, they lack cross‐neutralising antibodies to SARS‐CoV‐2.Therefore, passive virus neutralisation appears to be not responsible for the beneficial effects of IVIG. Recently, it has been found that SARS‐CoV‐2 encodes a superantigen motif near its S1/S2 cleavage site that might trigger cytokine storm. As IVIG contains antibodies reacting against SARS‐CoV‐2 antigens, IVIG might inhibit superantigen‐mediated T‐cell activation and cytokine release

Valuable opinion
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IVIG .. IN PARVOVIRUS..SARSCOV-2 .. COMPLICATED ..WITH. ANEMIA.. IS LIMITED & USEFUL..

Tnx Dr Ashok Leel sir
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IVIG has been used to treat chronic infections, such as parvovirus infection complicated by anemia. Presently, experience with the use of IVIG in the treatment of SARS-CoV-2 infection is very limited. The rationale for the use of IVIG in SARS-CoV-2 infection is modulation of inflammation

Agree with Dr Kute Ankush

Thanks Dr Kute Ankush
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USEFUL EDUCATIVE UPDATE

IVIG is used in chronic infections.,In Covid ,use is limited..

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