Sciencedirect: COVID-19 infection: Is the outcome time-dependent?

Coronavirus disease 2019 (COVID-19) is an infectious disease that can progress rapidly from asymptomatic to acute respiratory distress syndrome (ARDS), refractory coagulopathy and multiorgan failure. A recent pathological anatomical study [6], starting on emerging observations that suggest that COVID-19 has clinical features distinct from typical ARDS, has recognized the role of an intense complement activation that could lead to diffuse thrombotic microangiopathy and end organ dysfunction; a complement inhibitor (i.e. a humanized anti-C5 monoclonal antibody, eculizumab) might be considered in severe COVID-19. In line with these considerations, further treatment against COVID-19 seems to be represented by an other recombinant humanized monoclonal antibody, named tocilizumab, which binds the human IL-6 receptor, inhibiting its signal transduction. Chinese researches [7] have achieved encouraging results in 21 patients with severe COVID-19 pneumonia. Currently, COVID-19 infection does not have specific antiviral drug treatment, so the treatment of the disease must be focused on check the progression of the inflammatory cascade. The “time factor” seems to be important in both the development and treatment of this disease: it appears necessary to block early the “cytokine storm”. We feel like stating that the oxygen therapy and the mechanical ventilatory support in critically ill COVID-19 patients are not intended “to cure” but to “take time”, as a bridge therapy while the immune system faces the “cytokine storm”. Based on these considerations, we can hypothesize that an early diagnosis and an early blockage of inflammatory and thrombotic cascades than at the end-stages, with an immunological treatment and an anticoagulant therapy, are fundamental elements to improve the outcome of patients with COVID-19 infection. Source-



Nice article. Nice to learn. Thanks for sharing.

Now the people are suffering from covid19.... in homeopathy there are too many proved medicines are there....if the medicine given single dose with in three houres all the symptoms of thevcovid 19 are disappeared ....with in three days the patients cured 80%... after continue the medicine 100% cured......but our government not listen ....they only go through english medicin......if any one doctor having covid patients ...pls contact..I will send the mediciine..

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