Sir what is Mechanism of action of tacrolimus and amlenox in ulcer healing with dosage



Amlexanox The only prescription medication approved by the U.S. Food and Drug Administration (FDA) for treatment of aphthous stomatitis is amlexanox (Aphthasol) 5% paste. It accelerates healing through an unknown mechanism that inhibits release of inflammatory mediators (histamine and leukotrienes) from mast cells, neutrophils, and mononuclear cells. This agent has no direct analgesic properties. Topical tacrolimus and pimecrolimus are effective topical calcineurin inhibitors (TCI), which are anti-inflammatory agents that allow treatment of inflammatory dermatoses without the adverse effects of topical corticosteroids. They are already approved for the treatment of atopic dermatitis and ulcer. Same is the story with REBEPREMIDE...

Thank you doctor

Tacrolimus is an immunosuppressant It inhibits calcineurin phosphatase,cell degranulation and apoptosis. Mainly used to treat severe apoptotic dermatitis. Amlenox accelerates healing of ulcers by increasing the release of inflammatory mediators like histamine. Also known as Apthasol

Amlenox inhibit inflamatory mediators like histamin and leucotriens from mast cells and neutrophilis.

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Agree with dr. @Asfiya Khanum

Thankyou sir

Amlexanox oral paste, 5%, is indicated for the treatment of aphthous ulcers in people with normal immune systems.

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