Skin autofluorescence can predict type 2 diabetes and heart disease New research published online Nov. 21, 2018 in the journal Diabetologia has shown that non-invasive skin autofluorescence measurement predicts incident type 2 diabetes, cardiovascular disease and mortality in the general population independent of several traditional risk factors such as obesity, metabolic syndrome, glucose and A1c. A 1-unit higher skin autofluorescence was associated with a 3-fold increase in risk of type 2 diabetes or CVD, and a five times increased risk of death. A newly described noninvasive method to assess tissue AGEs concerns skin autofluorescence. This method is based on the specific fluorescence characteristics of AGEs and has been validated against specific AGE levels in skin biopsies in patients with diabetes or on hemodialysis and in healthy control subjects (9,10). Recently, the relationship between skin autofluorescence, reflecting AGE accumulation, and outcome has been studied in type 2 diabetes. Besides its relation with chronic diabetes complications (in cross-sectional analyses), skin autofluorescence has also shown independent predictive value for cardiovascular mortality and morbidity in patients with type 2 diabetes and in patients with end-stage renal disease undergoing hemodialysis (10–12) In this study, we analyzed whether skin autofluorescence, as a marker of AGE accumulation, can predict the development of microvascular complications in a type 2 diabetic population. Published ahead of print at http://care.diabetesjournals.org on 26 November 2007. DOI: 10.2337/dc07-1755.

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