Weber christian disease?


Pfeifer-Weber-Christian Disease (PWCD) is a rare inflammatory disorder of subcutaneous adipose tissue. It is also known as ideopathic relapsing febrile lobular non-suppurative panniculitis and is characterized by recurrent subcutaneous inflammatory painful nodules, fever, and malaise due to systemic inflammation. PWCD is an exclusion diagnosis, when no other cause of the lobular panniculitis can be identified. The most important other causes of lobular panniculitis include systemic lupus erythematosus, α1-antitrypsin deficiency, lymphoma, trauma, pancreatitis, and certain types of infections. The characteristic painful nodules are observed primarily in the area of the lower extremities and the trunk. It is still debated if PWCD exists as a unique disease entity or if it is just a substitute for any lobular panniculitis with unknown cause.

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