Which is the first line therapy for the treatment of thromotic thrombocytopenic purpura?


Conclusion. The correct answer is Plasma exchange.Thanks Dr Parveen for the correct answer.Patienrs with thrombotic thrombocytopenic Purpura should be treated with urgently with plasma exchange to prevent or reduce neurologic and systemic complications.High - dose of corticosteroids are frequently given along with plasma exchange ,but no definite evidence for their efficacy is available .Rituximab has been used as a second line agent in refractory cases.

Medicines used to treat TTP include glucocorticoids, vincristine, rituximab, and cyclosporine A. Sometimes surgery to remove the spleen (an organ in the abdomen) is needed. This is because cells in the spleen make the antibodies that block ADAMTS13 enzyme activity

Thank you doctor

PLASMA PHERESIS remains the first line treatment of TTP . This is an exchange transfusion involving removal of persons plasma through pheresis and replacement of donor plasma either FFP or cryosupernatant

Thanks Dr praveen for the right answer.

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