Which region of brain lack a significant blood- brain barrier?

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Four areas of the brain are not protected by the blood-brain barrier. These areas include the posterior pituitary gland, pineal gland, the median eminence of the hypothalamus and the area postrema.

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CONCLUSION Thanks for the answer. Brain regions that lack a significant blood- brain barrier tend to be the midline structures located near the ventricular space.They includethe area postrema,median eminence of the hypothalamus,and neurohypophysis.