why antihistamines cause sedation

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ntihistamines cause sedation as they are highly lipid soluble and readily cross the blood brain barrier. This sedating activity is sometimes used in managing conditions such as eczema where sleep maybe disturbed due to pruritus. Newer antihistamines such as loratadine (Claritin) and fexofenadine (Allegra) have been shown in clinical trials to cause less drowsiness than first-generation antihistamines.

As antihistaminics do crosses central blood brain barriers and suppress. Histamine release hence sedation

Thanx dr Pranab Bera
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Anti-histamines are classified into First Generation (sedating) and Second Generation (non-sedating) . Sedation is due to its high lipid solubility property that enables the drugs to cross blood-brain- barrier. However, at high dose of second generation anti-histamine , they may also cause sedation.

They can cross the blood-brain barrier and inhibit one of the other functions of histamines — hence resulting sedation

I am agree with@Dr. Dineshchandra Sharma Sir, and@Dr. Shivraj Agarwal Sir

Thanx dr
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Lipid by chemical nature crossing bbb

NICELY DISCUSSED. IN. DETAILS.. ..THANKS. SIR

I agree with @Dr. Dineshchandra Sharma

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