Worsening bilateral periorbital discoloration

A 44 y-o female presented with a 2-year history of worsening bilateral periorbital discoloration, pain, and swelling. Examination revealed yellow, firm plaques with surrounding erythema, and bilateral periorbital edema. Visual acuity, pupils, and extraocular motility were normal. What are your comments on the case?

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Suggestive of "Periorbital  Necrobiotic xanthogranuloma" NXG is a rare non-Langerhans histiocytosis with cutaneous manifestations, most commonly of the periorbital skin, and is often associated with hematologic disorders such as monoclonal gammopathy. Adv:- Biopsy

Tnx "Dr.Ashok leel Sir"
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* Amyloidosis ** Eczematous dermatitis may be due some allergic reaction Needs further investigation and evaluation to conclude and line of treatment.

Thanks Dr Dinesh Gupta
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Chr periorbital Allergic dermititis with secondary fungal infection

Thanx dr Ashok Leel
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Bilateral recurrent exematous dermatitis most probably due to food allergy or drug allergy

PERIORBITAL AMYLOIDOSIS/PERIORBITAL NECROBIOTIC XANTHOGRANULOMA

Thanks Dr. Dinesh Gupta
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Necrobiotic xanthogranuloma No first-line NXG therapy has been established. The recommended therapies of corticosteroids (intralesional and/or systemic), alkylating agents (such as cyclophosphamide, melphalan, or chlorambucil), interferon alfa, antimetabolites, antimicrobial treatment, and plasmapheresis have shown inconsistent success.

SUGGESTIVE OF PERIORBITAL AMYLOIDOSIS.... ... POSSIBLY... MYELOMA. ASSOCIATED... ADVISABLE BIOPSY....FOR. EARLY. DIAGNOSIS

DD:- Dermatitis, Fungal infection, Amyloidosis. Autoimmune disorders like SLE must be ruled out.

Chronic periorbital Eczematous dermatitis secondary to to Fungal infection

Amyloidosis.gradual discoloration around the eyes due to slow capillary ooze.

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