Acro-dermato-ungual-lacrimal-tooth syndrome

A rare genetic disorder with an autosomal dominant pattern of inheritance. It is associated with mutations in the MSX-1 gene on chromosome 4 which alter ectodermal morphogenesis. Characteristic clinical signs include absent or poorly-formed dentition and brittle, spoon-shaped finger and toenails. Clinical course features an increased incidence of dental caries but is essentially benign.

Disease Alternative Name

hypodontia with nail dysplasia
hypodontia-nail dysplasia
witkop syndrome
hypodontia and nail dysplasia
tooth and nail syndrome

Trending Cases