Aica-ribosuria

A ribonucleotide analog of adenosine monophosphate that is an intermediate in the synthesis of inosine monophosphate with potential cardioprotective activity. During myocardial ischemia, AICA-ribotide activates AMP-dependent protein kinase (AMPK), inhibits adenosine deaminase (ADA) and causes increased synthesis of both adenosine and adenosine triphosphate (ATP). These activities prevent calcium overload, increase AMPK-dependent glucose uptake and improve blood flow to the heart. AMPK, a protein kinase complex, regulates several cellular systems including the uptake of glucose, the beta-oxidation of fatty acids, protein synthesis, and the biogenesis of both glucose transporter 4 (GLUT4) and mitochondria. ADA is a key enzyme involved in purine metabolism.

Disease Alternative Name

5-aminoimidazole-4-carboxamide ribonucleotide
zmp
(2r
3s
4r
5r)-5-(4-carbamoyl-5-aminoimidazol-1-yl)-3
4-dihydroxyoxolan-2-ylmethyl dihydrogen phosphate
aica ribotide
5-amino-4-imidazolecarboxamide ribotide
5-phosphoribosyl-4-carbamoyl-5-aminoimidazole
5-amino-1-beta-d-ribofuranosyl-
5-amino-1-(5-phospho-d-ribosyl)imidazole-4-carboxamide
1h-imidazole-4-carboxamide
5-amino-1-(5-o-phosphono-beta-d-ribofuranosyl)- (9ci)
aminoimidazole carboxamide ribonucleotide
aica ribonucleotide
5-amino-4-imidazole carboxamide ribonucleotide
5-amino-1-(5-o-phosphono-beta-d-ribofuranosyl)-1h-imidazole-4-carboxamide
aica-ribotide
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