Aminopterin syndrome-like sine aminopterin

A synthetic derivative of pterins with antineoplastic and immunosuppressive properties. As a folate analogue, aminopterin competes for the folate binding site of the enzyme dihydrofolate reductase, thereby blocking tetrahydrofolate synthesis, and resulting in depletion of nucleotide precursors and inhibition of DNA, RNA and protein synthesis. (NCI04)

Disease Alternative Name

4-amino-pga
aminopterin
4-aminofolic acid
4-aminopteroylglutamic acid
apga
aminopteroylglutamic acid
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