Amyloidosis cerbroarterial app-related

An autosomal dominant form of cerebral amyloid angiopathy caused by mutation(s) in the APP gene, encoding amyloid-beta A4 protein. The deposition of amyloid in cerebral blood vessels wall may lead to degenerative vascular changes that may result in cerebral hemorrhage. Mutation(s) in the APP gene may also cause autosomal dominant Alzheimer disease 1.

Disease Alternative Name

cerebral amyloid angiopathy
hereditary cerebral hemorrhage with amyloidosis-dutch type

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