Autoimmune lymphoproliferative syndrome 1a
A rare, primary immunodeficiency with an autosomal dominant pattern of inheritance but variable penetrance. It is the most common subtype of autoimmune lymphoproliferative syndrome (ALPS). It is usually caused by a germline mutation in the Fas gene that leads to defective Fas-induced apoptosis but in a minority of cases, it also may be attributed to a somatic Fas mutation. Disruption of Fas-induced apoptosis impairs lymphocyte homeostasis and immune tolerance. Characteristic laboratory findings include an increase in circulating, double-negative (CD4-/CD8-) T cells in the setting of immune-mediated anemia, thrombocytopenia and neutropenia. Clinical signs present in childhood include fatigue, pallor, bruising, hepatosplenomegaly and chronic, non-malignant, non-infectious lymphadenopathy. The clinical course is influenced by a strong association with other autoimmune disorders and an increased risk for developing Hodgkin and non-Hodgkin lymphoma.
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Epididymal cysts are fluid filled sacs that develop in the Epididymis. They occur for a number of reasons but are always benign and generally cause mild discomfort only. Dr. Vivek Jha is sharing a clinical case of "Epididymal cyst" managed with surgical expertise by him. Share your views on the case & learn new things.
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M.62 yrs Fever & chest pain 10 days.
Dr. Syam Sundar Patro0 Like7 Answers - Login to View the image
Dear doctor friends, Kindly suggest Rx. Female /55 years Diabetic Suffering from GANGRENE RIGHT FOOT *Chief Complaints* Swelling over right foot Bleeding from wound No pus Wound Not getting good *History* Diabetic type 2 *Vitals* PPS 180 BP 120/84 *Physical Examination* Deep bleeding wound but no pus *Investigations* The sonography report is attached *Diagnosis* Gangrene right feet, skin so thickened *Management* Regular dressing, controlled blood sugar, strictly following diet control
Chetna Vora1 Like5 Answers - Login to View the image
Secondary hypertension often affects younger patients & those with resistant or refractory hypertension. Identifying the underlying cause of secondary hypertension may lead to successful intervention with the potential to improve quality of life & reduce cardiovascular morbidity and mortality. Dr. Sanjay Jain is sharing a clinical case of “Secondary Hypertension - Pheochromocytoma management”. Share your views on the case.
Dr. Sanjay N Jain1 Like4 Answers - Login to View the image
X-rays are commonly used in clinical practice to diagnose fractures. Characteristics of the fracture such as the type, deformity & soft tissue / joint involvement are used to guide management. Learn & update your basic radiological approach for “Bone Fractures” & interpretation knowledge & patient care approach with this post.
Radiology Essential0 Like2 Answers