1. What are the 2 defects inherent in an individual with type 2 Diabetes with regard to incretins ?

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Two notable features in a known T2DM with regard to incretins : 1. GLP-1 deficiency 2. GIP resistance.

** Glucose-induced GLP-1 secretion is deficient in patients with NAFLD and NASH.. ** Gastric inhibitory polypeptide (GIP) .

Hip andGlp2

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