UPDATE ON VITAMIN D IN VIRAL INFECTIONS AND IT'S MECHANISM OF ACTION

Dear my friends and fellow Colleagues, Here is an update on Vitamin D in Viral Infections. In viral infection, lung epithelial cells are able to convert inactive vitamin D to active vitamin D, which in turn produces an increased amount of defensive and cathelicidins, antimicrobial peptides of the host defense system that kill pathogens or bind to endotoxin, forming ion channels and increasing membrane permeability. Regards and thanks, Dr Sepuri Krishna Mohan.

2 Likes

LikeAnswersShare
Sir - again thanks for the update on mechanism of vitamin D in countering viral infections. A little about cathelicidins,which are produced in increased amount by active Vitamin D or 1, 25 - D .Besides active vitamin D - cathelicidins are are also activated by bacteria, virus and fungus infection. Cathelicidins also called antimicrobial peptides ( AMP's) serve a critical role in human innate immune defense against invasive bacterial and viral infections. Originally found in neutrophils , but later also now found in many other cells like epithelial cells and macrophages- but only after activation by active vitamin D , bacteria, virus and fungus .Cathelicidins rapidly destroy the,lipoprotein membranes of microbes enveloped in phagosomes after fusion with lysosomes in macrophages Thanks
Wonderful analysis and summary dear Parveen
1
Wonderful role of vit d in viral infection educational discussion sir thanx
Thanks sir
Valuable opinion
0
Nice
I agree
0

Cases that would interest you