Excessive blackish over face since 1 month,plz interpretate diseasec and treatment

5yr old male child with loss of hair since one year

2and half year girl has complaints of hair loss over scalp and eyelashes since one month. she is also having complaints of weight loss. kindly guide in this case

A 37-year-old male presented to the ED with two days of chest pain . constant, rated at a level of 3 (on a scale of 0 to 10), and slightly worsening on deep inspiration. He described increased shortness of breath with exertion and a cough productive of clear sputum but denied fevers, chills, nausea, lightheadedness or sweating. The patient was a pale, obese male who appeared in no acute discomfort .temp - 97.5◦F ,1 Rr18 beats/minute BP 102/72 mmHg RR 18 Spo2 -96% CVS s1s2+ Rs : Rales at the lung bases bilaterally P/a Soft, nontender, nondistended. CNS Nonfocal. TLC 18 K/μL with 90% neutrophils, hematocrit - 31% creatinine - 1.5 mg/dL positive D-dimer. troponin I - normal

He is complaining of ,polyurea,polyphagia , polydiphsiya ,emaciated,malnourished ,all muscles shows signs of wasting,sunken eye ball,multiple bone preeminence with lipoatropic ,and altered bowled.History of behavioral disorders . Discuss the case. l