A 55 year old male with lower back ache. The histopathological image is shown below. what is the most likely diagnosis.

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- Lobules of Physaliferous cells ( Bubbly vacuolated appearance) separated by thin fibrous septae and intervening myxoid stroma Impression - Chordoma Most common site sacroccygeal region resulting in osteolytic lesions and presentation as lower back ache

IHC Brachyury expression is highly sensitive and specific for chordomas therefore it should be included as a useful specific marker in the IHC panel of chordomas along with sensitive but not so specific markers such as CK, EMA, and/or S100 protein.

Section shows foamy, vacuolated, physaliferous cell grows in distinct nodules It is a malignant tumor of primitive notochordal origin location occur in the sacrum and coccyx, spheno-occiptal region and inmobile spine. Chordoma

Nests of physalleferous cells separated by septa and myxoid rich connective tissue. Imp - chordoma.

Features are of Chordoma Physalipherous Cells Thanks for Sharing

Chordoma (NOS) classical IHC Brachyury +,CAM 5.2+

Chordoma - characteristic psyliferous cells

Chordoma

Physaliferous cells separated by thin fibrous delta.imp. Chordoma.

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